WebOct 5, 2024 · To explore the function of CDK12 in the kidney, we generated a novel CDK12 flox/flox line harboring loxP sites flanking exon 4 of the Cdk12 gene. By breeding with cdh16-Cre transgene mice, in which Cre expression is limited to the renal tubules, including Bowman’s capsule, proximal tubule, loop of Henle, distal tubule, and the collecting duct, … WebNov 7, 2016 · To detect conversion towards tubule cell identity, we crossed mice harbouring Cre-recombinase under control of the renal tubule-specific cadherin-16 promoter (Cdh16/Ksp-Cre (kidney-specific ...
Epithelial-specific Cre/lox recombination in the …
WebMay 15, 2024 · By breeding with cdh16-Cre transgene mice, in which Cre expression is limited to the renal tubules, including Bowman’s capsule, proximal tubule, loop of Henle, distal tubule, and the collecting duct, we … Web012237 B6.Cg-Tg(Cdh16-cre)91Igr/J These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may … footes sheds ny
Tubular-specific CDK12 knockout causes a defect in …
WebJul 1, 2014 · Epithelial specific knockout of Invs in Invs flox/flox;Cdh16-Cre mutant mice resulted in renal cyst formation and severe stromal fibrosis, while Invs flox/flox;Foxd1-Cre mice, where Invs is deleted in stromal cells, displayed no observable phenotypes up to the young adult stage, highlighting a significant role of epithelial-stromal crosstalk. WebJun 22, 2024 · Cdh16, also known as kidney specific protein (Ksp), is expressed in kidney distal nephrons including the loop of Henle, distal convoluted tubules, and collecting … WebApr 7, 2024 · EZH2 conditional knockout mice were generated by breeding our EZH2 fl/fl mice with Cdh16-Cre mice to obtain Cdh16-Cre +: EZH2 fl/fl mice (EZH2-cKO) and Cdh16-Cre −: EZH2 fl/fl mice (EZH2-WT). footes timaru