The ccl20-ccr6 axis in cancer progression
網頁2024年11月10日 · Chen et al. reported that CCR6 expression in cancer is elevated and connected with malignant progression. The upregulation of CCR6 has been observed in patients with GC in comparison to normal gastric tissue. CCL20 recruits other cells … 網頁2024年12月1日 · Additionally, transfection of Lewis lung carcinoma cells with CCR6 caused local production of CCL20 in the lung and reduced the metastatic possibility in mice [45]. In addition, a study with 84 patients of LUAD showed that higher expression of CCR6 in tumor was an independent predictor of a better prognosis in LUAD [46].
The ccl20-ccr6 axis in cancer progression
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網頁2024年7月1日 · CCL20 functions under physiological and inflammatory conditions through binding and activating CCR6, and the CCL20/CCR6 axis plays a vital role in tissue inflammation, infectious diseases, cancer progression, and autoimmune diseases (Furue et al., 2024; Kwantwi et al., 2024; Meitei et al., 2024). 網頁2024年7月22日 · The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling …
網頁2024年3月1日 · Cisplatin induces chemokine ligand 20 (CCL20) expression in CAMs in a time- and dose-dependent manner. CAM-secreted CCL20 subsequently binds to chemokine receptor 6 (CCR6) on ovarian cancer cells, activating epithelial-to-mesenchymal transition (EMT) to enhance ovarian cancer cell migration. 網頁2024年12月11日 · Our findings revealed that CCL20-CCR6 axis promotes ovarian cancer metastasis both in vivo and in vitro, probably through increasing cancer cell adhesion …
網頁2024年6月16日 · The CCL20-CCR6 axis promotes cancer progression directly by enhancing migration and proliferation of cancer cells and indirectly by remodeling the tumor … 網頁2024年3月22日 · The role of the CCL20 chemokine in hepatocellular carcinoma (HCC) is well described; the CCL20–CCR6 axis is considered to be a key factor in tumor …
網頁2024年1月1日 · CCL20, as a chemokine, plays an important role in rheumatoid arthritis, psoriasis, and other diseases by binding to its receptor CCR6. Recent 10 years' research has demonstrated that CCL20 also contributes to the progression of many cancers, such as liver cancer, colon cancer, breast cancer, pancreatic cancer, and gastric cancer.
網頁2024年11月15日 · The CCL20/CCR6 axis has been shown in many studies to contribute to the initiation and progression of HCC [7]. CCL20, also called liver activation regulated chemokine (LARC) or macrophage inflammatory protein-3 (MIP3α), is a chemokine [8] belonging to the CC chemokine family. dance teacher certification programs nyc網頁2024年7月5日 · Thus, the CCL20/CCR6 axis may serve a vital role in the DEPDC1-mediated progression of HCC. RT-qPCR was performed to validate the expression of CCL20 and CCR6. In congruence with microarray results, the expression of CCL20 and CCR6 in Huh-7 cells treated with DEPDC1 siRNA was significantly lower compared with … dance teacher jobs dorset網頁2024年3月1日 · Here, we demonstrated that cisplatin-stimulated classically activated macrophages (CAMs) promote ovarian cancer cell migration by increasing CCL20 … bird with large mouth網頁Progressive attention has been given to the role of CCL20-CCR6 axis in immune regulation and mechanism in autoimmune diseases. Our study preliminarily explored the role of CCL20-CCR6 axis in the resistance of myeloma immunotherapy with the aim of providing a new target for immunotherapy, reverse the resistance of myeloma cells to immunotherapy. dance teacher jacket網頁2024年12月11日 · The role of chemokines/receptors in the pathophysiological activities such as inflammation and tissue injury has been clarified. In recent years, there have been increasing studies on their effect on tumors in the tumor microenvironment. This article reviews research advances in C-C motif chemokine ligand 20 (CCL20) and its receptor … bird with largest vocabulary網頁2024年4月11日 · Platinum drugs, such as cisplatin, can change the anticancer activity of M1 macrophages and induce migratory characteristics in OC cell lines via the CCL20-CCR6 axis [26]. Mechanistically, TAMs promote the spread of OC along the mesothelial-lined peritoneal cavity by facilitating OC cell adhesion to mesothelial cells via P-selectin … dance teacher glee season 4網頁2024年2月3日 · A chemokine array identified the CCL20-CCR6 axis as a concentration-dependent signal in ACHN and Caki-1 cell migration. Akt in the ACHN and Caki-1 cells was activated by macrophage-like cells, and the CCL20 neutralizing antibody suppressed migration ability, epithelial–mesenchymal transition, and Akt phosphorylation in the ACHN … dance teacher cv examples